US PATENT SUBCLASS 930 / 31
.~.~ Retro-inverted


Current as of: June, 1999
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930 /   HD   PEPTIDE OR PROTEIN SEQUENCE

10  DF  PEPTIDE OR PROTEIN SEQUENCE {31}
30  DF  .~ Linear peptide or protein containing a nonpeptide or abnormal peptide link (See note 5) {1}
31.~.~ Retro-inverted


DEFINITION

Classification: 930/31

Retro-inverted:

Subject matter under cross-reference art collection 30 containing a peptide or protein which is retro-inverted.

(1) Note. Retro-inversion is a way of protecting peptide substances against proteolysis. It entails retro-inverting those peptide bonds most susceptible to enzymatic hydrolysis by inverting the direction of the peptide bonds. The "retro-inverso peptides" are structural isomers of the reference peptides and as such preserve their biological activity while being more resistant to enzymatic hydrolysis.